Invitrogen™ ITK Monoclonal Antibody (5G6)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA515879

Product Code. 12827902

Description

MA5-15879 targets ITK in indirect ELISA, flow cytometry, Western blot, and immunofluorescence applications and shows reactivity with Human samples. The MA5-15879 immunogen is purified recombinant fragment of human ITK expressed in E. Coli. . MA5-15879 detects ITK which has a predicted molecular weight of approximately 72kDa.

ITK is a tyrosine kinase expressed in T-cells which contains both SH2 and SH3 domains. ITK is thought to play a role in T-cell proliferation and differentiation. The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Itk (also known as Emt or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini. Itk associates with CD28 and becomes activated subsequent to CD28 ligation.

Specifications

• Antigen: ITK
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Gene Accession No.: Q08881
• Gene Symbols: ITK
• Immunogen: Purified recombinant fragment of human ITK expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 3702
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: 5G6
• Conjugate: Unconjugated
• Gene: ITK
• Gene Alias: EMT; homolog of mouse T-cell itk/tsk; IL2 inducible T cell kinase; IL2 inducible T-cell kinase; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; interleukin-2-inducible T-cell kinase; ITK; Kinase EMT; kinase TLK; LPFS1; LYK; MGC126257; MGC126258; PSCTK2; T-cell-specific kinase; Tcsk; Tlk; Tsk; Tyrosine-protein kinase ITK/TSK; tyrosine-protein kinase LYK
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1