ITI-214, MedChemExpress

Product Code. 16491427

Brand: Medchem Express HY12501A

Description

MedChemExpress ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions.

ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions.

Specifications

• Chemical Name or Material: ITI-214
• CAS: 1642303-38-5
• Color: White
• Purity Grade Notes: Research
• Molecular Formula: C₂₉H₂₉FN₇O₅P
• Quantity: 50 mg
• Solubility Information: DMSO : ≥ 30 mg/mL (49.54 mM)
• SMILES: O=C(C1=C(NC2=CC=CC=C2)N(CC3=CC=C(C4=NC(F)=CC=C4)C=C3)N=C1N56)N(C)C5=N[C@@]7([H])[C@]6([H])CCC7.O=P(O)(O)O
• Molecular Weight (g/mol): 605.56
• Formula Weight: 605.56
• Percent Purity: 99.54%
• Grade: Research
• Physical Form: Solid
• For Use With (Application): Neuroscience-Neuromodulation

Research purposes only