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Invitrogen™ IRS1 Polyclonal Antibody

Product Code. 12848302
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12848302 100 μg 100µg
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Product Code. 12848302 Supplier Invitrogen™ Supplier No. PA520137

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Description

Rabbit Polyclonal Antibody

A suggested positive control is PC-3 cell lysate. PA5-20137 can be used with blocking peptide PEP-0344.

IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRS1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene IRS1
Gene Accession No. P35568, P35569
Gene Alias G972R; HIRS-1; Insulin receptor substrate 1; IRS1; IRS-1; IRS1IRM; pp185
Gene Symbols IRS1
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the center of human IRS-1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16367, 3667
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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