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Invitrogen™ IRF8 Polyclonal Antibody

Product Code. 12858292
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Quantity:
100 μg
Unit Size:
100µg
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12858292 100 μg 100µg
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Product Code. 12858292 Supplier Invitrogen™ Supplier No. PA520088

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human thymus tissue lysate. PA5-20088 can be used with blocking peptide PEP-0206.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRF8
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Irf8
Gene Accession No. P23611, Q02556
Gene Alias AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
Gene Symbols Irf8
Host Species Rabbit
Immunogen A peptide corresponding to 16 amino acids near the carboxy terminus of human IRF8.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15900, 292060, 3394
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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