IRF8 Mouse anti-Human, Mouse, PE, Clone: V3GYWCH, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9852-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15537246

Quantity Price
1 £ 205.24 / 100µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Concentration 0.2mg/mL
Format Conjugated
Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Clone V3GYWCH
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Human, Mouse
Primary or Secondary Primary
Conjugate PE
Applications Flow Cytometry (Intracellular Staining)
Quantity 100μg
Host Species Mouse
Antigen IRF8
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO

The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid DC (pDC) and CD8a+ DC. IRF8-/- mice are deficient in both pDC and CD8a+ DC populations. CD8a- DC are present in normal numbers in IRF8-/- mice but fail to mature upon Toll-like receptor signaling and are functionally impaired in response to in vivo microbial stimulation. IRF8 deficiency does not affect the frequency or viability of DC precursors and as a result retroviral IRF8 transduction restores pDC development from DC progenitors in IRF8-/- mice.