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IRF4 Monoclonal Antibody (3E4), PE-Cyanine7, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£93.00 - £231.00
Specifications
Antigen | IRF4 |
---|---|
Clone | 3E4 |
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15508686
|
Affymetrix eBioscience
25-9858-80 |
25 μg |
£93.00
25µg |
Estimated Shipment: 13-05-2024 Log in to see stock. |
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15518686
|
Affymetrix eBioscience
25-9858-82 |
100 μg |
£231.00
100µg |
Estimated Shipment: 11-06-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Description: The monoclonal antibody 3E4 reacts with human and mouse interferon regulatory factor 4 (IRF4). IRF4 is a 52 kDa transcription factor with roles in B cell, T cell and macrophage function. In B cells, IRF4 is highly expressed in mature plasma cells and plays a crucial role in their differentiation. IRF4 has been shown to interact with PU.1 and control the transcription of many B cell-specific genes including Prdm1, which encodes Blimp1. In T cells, IRF4 has been implicated in regulatory T (Treg), Th2, Th9 and Th17 cell development and function. This transcription factor is upregulated upon T cell activation and is expressed in mature T cells. Studies have shown that IRF4 directly induces Blimp1 expression in Tregs, leading to IL-10 expression. IRF4 has also been demonstrated to be involved in macrophage polarization and regulation. Lastly, in addition to its roles in normal immune function, IRF4 expression has been reported to be upregulated in many blood-related cancers. Applications Reported: This 3E4 antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This 3E4 antibody has been tested by intracellular staining and flow cytometric analysis of stimulated normal human peripheral blood cells using the Foxp3/Transcription Factor Buffer Set (cat 00-5523) and protocol.
IRF4 Monoclonal antibody specifically detects IRF4 in Human, Mouse samples. It is validated for Flow Cytometry.Specifications
IRF4 | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
AI385587; interferon regulatory factor 4; Irf4; IRF-4; LSIRF; Lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1; MUM1; NF-EM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; SHEP8; Spip; Transcriptional activator PIP | |
IRF4 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
IRF4 |
3E4 | |
Flow Cytometry | |
PE-Cyanine7 | |
Rat | |
Human, Mouse | |
Q15306, Q64287 | |
16364, 3662 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.