Invitrogen™ IREB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA564388

Product Code. 15732152

Description

Immunogen sequence: EYGAILSFFP VDNVTLKHLE HTGFSKAKLE SMETYLKAVK LFRNDQNSSG EPEYSQVIQI NLNSIVPSVS GP Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.

Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).

Specifications

• Antigen: IREB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IREB2
• Gene Alias: ACO3; D9Ertd85e; FLJ23381; im:7153062; Ireb2; IRE-BP 2; IREBP2; Iron regulatory protein 2; iron responsive element binding protein 2; iron-regulatory protein 2; iron-responsive element binding protein 2; iron-responsive element-binding protein 2; Iron-responsive element-binding protein 2-like protein; IRP2; IRP2AD
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3658
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P48200
• Gene Symbols: IREB2
• Immunogen: Recombinant protein corresponding to Human IREB2. Recombinant protein control fragment (Product #RP-104254).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG