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Invitrogen™ IRAK2 Polyclonal Antibody

Product Code. 12848152
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Quantity:
100 μg
Unit Size:
100µg
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12848152 100 μg 100µg
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Product Code. 12848152 Supplier Invitrogen™ Supplier No. PA519937

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~65kDa. A suggested positive control is K562 cell lysate. PA5-19937 can be used with blocking peptide PEP-0062.

IRAK2 (interleukin-1 receptor-associated kinase-like 2) binds to the IL-1 type I receptor following IL-1 engagment and triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa-B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa-B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa-B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRAK2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene IRAK2
Gene Accession No. O43187
Gene Alias 6330415L08Rik; AI649099; interleukin 1 receptor associated kinase 2; interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase 2c; interleukin-1 receptor-associated kinase-like 2; Irak2; IRAK-2; MGC150550; mu-IRAK-2
Gene Symbols IRAK2
Host Species Rabbit
Immunogen A peptide corresponding to amino acids near the carboxy terminus of human IRAK2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3656
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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