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Invitrogen™ IRAK1 Monoclonal Antibody (8F1A7)

Product Code. 12807812
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Quantity:
100 μg
Unit Size:
100µg
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12807812 100 μg 100µg
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Product Code. 12807812 Supplier Invitrogen™ Supplier No. MA515783

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Description

Mouse Monoclonal Antibody

A suggested positive control is IRAK recombinant protein.

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRAK1
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 8F1A7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Irak1
Gene Accession No. P51617, Q62406
Gene Alias AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841
Gene Symbols Irak1
Host Species Mouse
Immunogen Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16179, 363520, 3654
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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