Invitrogen™ IQSEC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA538019

Product Code. 15534951

Description

A recommended positive control is A-20 cell lysate. At least four isoforms of IQSEC1 are known to exist. IQSEC1 antibody is not expected to cross-react with IQSEC2.

ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.

Specifications

• Antigen: IQSEC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IQSEC1
• Gene Alias: ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARFGEP100; ARF-GEP100; AW561907; BC026481; BRAG2; brefeldin A-resistant ARF-GEF2; brefeldin-resistant Arf-GEF 2 protein; cI-43; D6Ertd349e; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; Iqsec1; Kiaa0763
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 232227, 686590, 9922
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q6DN90, Q8R0S2
• Gene Symbols: IQSEC1
• Immunogen: 19 amino acid peptide near the amino terminus of human IQSEC1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG