Invitrogen™ IPO5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA596023

Product Code. 16578861

Description

Immunogen sequence: AAAAAEQQQF YLLLGNLLSP DNVVRKQAEE TYENIPGQSK ITFLLQAIRN TTAAEEARQM AAVLLRRLLS SAFDEVYPAL PSDVQTAIKS ELLMIIQMET QSSMRKKVCD IAAELARNLI DEDGNNQWPE GLKFLFDSVS SQNVGLREAA LHIFWNFPGI FGNQQQHYLD VIKRMLVQCM QDQEHPSIRT LSARATAAFI LANEHNVALF KHFADLLPGF LQAVNDSCYQ NDDSVLKSLV EIADTVPKYL RPHLEATLQL SLKLCGDTSL NNMQRQLALE V; Positive Samples: SW620, HeLa, 293T, HepG2, Mouse testis, Mouse brain; Cellular Location: Cytoplasm, Nucleus, nucleolus Excitation: 405 nm; Emission: 645 nm; Laser: Blue Laser.

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

Specifications

• Antigen: IPO5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IPO5
• Gene Alias: 1110011C18Rik; 5730478E03Rik; AA409333; C76941; IMB3; imp5; importin 5; importin beta-3 subunit; importin subunit beta-3; Importin-5; IPO 5; IPO5; karyopherin (importin) beta 3; Karyopherin beta 3; karyopherin beta-3; Kpnb3; MGC2068; Pse1; RAN binding protein 5; Ran_GTP binding protein 5; ran-binding protein 5; RanBP 5; Ranbp5
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 306182, 3843, 70572
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3.31 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O00410, Q8BKC5
• Gene Symbols: IPO5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human IPO5 (NP_0022623).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG