2-Iodoacetamide, 98%, stab. with ca 5-8% water


Overview
Brand: Alfa Aesar

Manufacturer Part Number: A14715-06

IODOACETAMIDE, 98% 5G

UNSPSC: 12352106

Code: NEW

Additional Details:
Additional Details: CAS Number: 144-48-9 Weight: 0.01000kg


Quantity 5g

Product Code. 11467736

Quantity Price
1 £ 14.2 / 5g
Estimated Shipment date
from Supplier 09-12-2016
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Description and Specification

Chemical Identifiers

Chemical Name or Material Iodoacetamide
CAS 144-48-9
Name Note stabilized with ≈5 to 8% water
Molecular Formula ICH2CONH2
Formula Weight 184.96g/mol
MDL Number MFCD00008028
UN Number UN2811
Beilstein 1739080

Specification

Quantity 5g
Chemical Name or Material Iodoacetamide
Name Note stabilized with ≈5 to 8% water
CAS 144-48-9
Assay 98%
Assay Percent Range 98%, stabilized with ca 5% water
Molecular Formula ICH2CONH2
Formula Weight 184.96g/mol
MDL Number MFCD00008028
UN Number UN2811
Beilstein 1739080
Health Hazard 1 Danger
Health Hazard 2 GHS H Statement
H301-H315-H319-H317-H335
Toxic if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause an allergic skin reaction.
May cause respiratory irritation.
Health Hazard 3 GHS P Statement
P261-P280-P301+P310-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF SWALLOWED: Immediately call a POISON CENTER
Recommended Storage 2° to 8°C
DOT Information Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
RTECS Number AC4200000
TSCA TSCA

Applications
Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.

Solubility
Soluble in water, dimethyl formamide and ethanol. Slightly soluble in methanol.

Notes
Store in a cool place. Light and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Safety and Handling

Danger

GHS H Statement
H301-H315-H319-H317-H335
Toxic if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause an allergic skin reaction.
May cause respiratory irritation.

GHS P Statement
P261-P280-P301+P310-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF SWALLOWED: Immediately call a POISON CENTER

2° to 8°C