Involucrin Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16896805	Proteintech 55328-1-AP-20UL	20 μL
16886805	Proteintech 55328-1-AP-150UL	150 μL

Description

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premaligt lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.

Specifications

• Antigen: Involucrin
• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P07476, P48997
• Gene ID (Entrez): 16447, 3713
• Immunogen: Peptide
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: IVL

• Concentration: 0.13 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: involucrin, IVL
• Gene Symbols: Ivl
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody