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Integrin beta 7 Monoclonal Antibody (FIB504), FITC, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£166.00
Specifications
Clone | FIB504 |
---|---|
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Conjugate | FITC |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15526576
|
Affymetrix eBioscience
11-5867-42 |
100 Tests |
£166.00
100 tests |
Estimated Shipment: 15-05-2024 Log in to see stock. |
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Description
Description: The FIB504 monoclonal antibody reacts with human and mouse integrin beta 7. Integrin beta 7 is a 130 kD glycoprotein which associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha 4 beta 7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alpha E beta 7 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity. Applications Reported: This FIB504 antibody has been reported for use in flow cytometric analysis. Applications Tested: This FIB504 antibody has been tested by flow cytometric analysis of human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.Specifications
FIB504 | |
Flow Cytometry | |
FITC | |
Rat | |
Human, Mouse | |
ITGB7 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
ITGB7 |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
16421, 3695 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.