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Integrin beta 7 Antibody (FIB27), PE, Novus Biologicals™

Product Code. 18350530 Shop All Bio Techne Products
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0.1 mL
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18350530 0.1 mL 0.1mL
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Product Code. 18350530 Supplier Novus Biologicals Supplier No. NBP281087PE

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Description

Rabbit Monoclonal Antibody

Integrin beta 7 Monoclonal specifically detects Integrin beta 7 in Human, Mouse samples. It is validated for Flow Cytometry.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin beta 7
Applications Flow Cytometry
Classification Monoclonal
Clone FIB27
Conjugate PE
Dilution Flow Cytometry
Formulation PBS
Gene Alias Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7
Gene Symbols ITGB7
Host Species Rabbit
Immunogen FIB27 was prepared by immunizing rats with TK1 cells.
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 3695
Test Specificity FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.
Target Species Human, Mouse
Content And Storage Store at 4°C in the dark.
Form Purified
Isotype IgG κ
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