Integrin alpha-6 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16825465	Proteintech 27189-1-AP-20UL	20 μL
16815465	Proteintech 27189-1-AP-150UL	150 μL

Description

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Specifications

• Antigen: Integrin alpha-6
• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P23229
• Gene ID (Entrez): 3655
• Immunogen: Integrin alpha-6 Fusion Protein Ag25835
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ITGA6

• Concentration: 0.23 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: CD49f, Integrin alpha 6, Integrin alpha-6, integrin, alpha 6, ITGA6, ITGA6B, VLA 6
• Gene Symbols: ITGA6
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody