Integrin alpha 4 beta 7 (LPAM-1) Rat anti-Mouse, PE, Clone: DATK32 (DATK-32), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5887-83

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15258879

Quantity Price
1 £ 176.7 / 200µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Isotype IgG2a
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Antigen Integrin alpha 4 beta 7 (LPAM-1)
Quantity 200μg
Concentration 0.2mg/mL
Host Species Rat
Species Reactivity Mouse
Regulatory Status RUO
Conjugate PE
Applications Flow Cytometry
Clone DATK32 (DATK-32)
Format Conjugated

The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (alpha 4/ beta 7), which is a heterodimer of the the 154kDa alpha 4 subunit and the 130kDa beta 7 subunit. In mouse, the beta 7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.