Integrin alpha 4 beta 7 (LPAM-1) Rat anti-Mouse, Clone: DATK32 (DATK-32), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5887-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15277557

Quantity Price
1 £ 54.42 / 100µg
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone DATK32 (DATK-32)
Quantity 100μg
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Antigen Integrin alpha 4 beta 7 (LPAM-1)
Isotype IgG2a
Regulatory Status RUO
Applications Flow Cytometry
Applications Functional Assay
Format Purified
Primary or Secondary Primary
Species Reactivity Mouse
Concentration 0.5mg/mL
Host Species Rat
Storage Requirements Store at 2-8°C.

The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (α4β7), which is a heterodimer of the the 154kDa α4 subunit and the 130kDa β7 subunit. In mouse, the β7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.