Integrin alpha 4 beta 7 (LPAM-1) Rat anti-Mouse, Clone: DATK32 (DATK-32), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5887-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15267557

Quantity Price
1 £ 36.08 / 50µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Quantity 50μg
Applications Flow Cytometry
Applications Functional Assay
Isotype IgG2a
Format Purified
Primary or Secondary Primary
Host Species Rat
Storage Requirements Store at 2-8°C.
Clone DATK32 (DATK-32)
Concentration 0.5mg/mL
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen Integrin alpha 4 beta 7 (LPAM-1)
Species Reactivity Mouse

The DATK32 monoclonal antibody binds to a combinatorial epitope of mouse LPAM-1 (α4β7), which is a heterodimer of the the 154kDa α4 subunit and the 130kDa β7 subunit. In mouse, the β7 subunit is found on the majority of mature lymphocytes and a small population of thymocytes and bone marrow cells. LPAM-1 is an integrin involved in the transendothelial migration of lymphocytes across high endothelial venules (HEV), and is know to bind several ligands including MAdCAM-1, VCAM-1 and fibronectin. Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block LPAM-1-mediated cell adhesion.