Invitrogen™ Insulin/Proinsulin Monoclonal Antibody (D3E7 (5B6/6))

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA183256

Product Code. 11524633

Description

This product has an Affinity of 6.3x10^8 M^-1. Mouse anti Human Insulin/Proinsulin antibody, clone D3E7 (5B6/6) recognizes both insulin and proinsulin, but does not react with free C-peptide.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

Specifications

• Antigen: Insulin/Proinsulin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with <0.1% sodium azide
• Gene Accession No.: P01308, P01315, P01317, P01322, P01323, P01325, P01326
• Gene Symbols: INS, Ins1, Ins2
• Immunogen: Recombinant human insulin.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Bovine, Pig
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Clone: D3E7 (5B6/6)
• Conjugate: Unconjugated
• Gene: INS
• Gene Alias: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 16333, 16334, 24505, 24506, 280829, 3630, 397415
• Content And Storage: -20°C
• Form: Liquid