INSR Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA587412

Product Code. 16565901

Description

Positive Samples: Mouse liver, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein Immunogen sequence: PPTLQEMIQM AAEIADGMAY LNAKKFVHRD LAARNCMVAH DFTVKIGDFG MTRDIYETDY YRKGGKGLLP VRWMAPESLK DGVFTTSSDM WSFGVVLWEI T

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

Specifications

• Antigen: INSR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: INSR
• Gene Alias: 4932439J01Rik, CD 220, CD220, CD220 antigen, CD220 beta, CD221, D630014A15Rik, HHF 5, HHF5, IGF-I receptor, INSR, Insulin receptor, insulin receptor preproprotein, Insulin receptor subunit alpha, Insulin receptor subunit beta, IR, IR 1, IR beta, IR1, IR-1, IR-A, IR-B
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16337, 3643
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.79 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene Accession No.: P06213, P15208
• Gene Symbols: INSR
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1130-1230 of human Insulin Receptor (NP_0001992)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG