Invitrogen™ Influenza A PA (A/WSN/1933) Recombinant Rabbit Monoclonal Antibody (HL1388)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA547024

Product Code. 17819335

Description

Store as concentrated solution. Centrifuge briefly prior to opening vial.

Influenza viruses consists of three types (Influenza A, B, and C), which make up three of the five genera in the Orthomyxoviridae family. Commonly know as the flu, influenza strains can affect both birds and mammals. Influenza strains form roughly spherical particles and are similar in composition with viral envelope containing two main types of glycoproteins (hemagglutinin and neuraminidase), wrapped around the central core of the viral RNA genome and other viral proteins that package and protect the RNA. Unusually for a virus, the influenzavirus genome is not a single piece of nucleic acid; rather a seven to eight segmented fragments of negative-sense RNA with each fragment expressing different viral proteins. Influenza spreads seasonally, resulting in about three to five million yearly cases of severe illness and about 250,000 to 500,000 deaths annually or into the millions in pandemic years. Influenza A virus contains eight single stranded, negative sense RNAs. Each RNA is associated with viral RNA-dependent RNA polymerase which consists of PA, PB1 and PB2 proteins. Recent reports indicate the involvement of PA in 'cap-snatching' mechanism via its endonuclease activity which is essential for cRNA-dependent viral RNA synthesis.

Specifications

• Antigen: Influenza A PA (A/WSN/1933)
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Clone: HL1388
• Conjugate: Unconjugated
• Gene Alias: Influenza PA
• Immunogen: Recombinant protein encompassing a sequence within the C-term region of Influenza A virus PA protein (A/WSN/1933(H1N1)). The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid