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DiscoverX InCELL Hunter™ U2OS Bcl2-Bax Protein Binding Cell Line

Product Code. 17334769
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17334769

Brand: DiscoverX 960010C3

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This item is not returnable. View return policy

Description

The InCELL Hunter™ U2OS Bcl2-Bax Protein Binding Cell Line measures protein binding via compound-induced binding partner disruption and degradation. This cell line ships as two vials of cryopreserved cells.

The InCELL Hunter™ U2OS Bcl2-Bax Protein Binding Cell Line provides an easy-to-use cell based assay to study small molecule drug candidates that disrupt protein binding. This kit assesses compound-based disruption of Bcl2-Bax binding via detection of Bax levels. This product uses EFC technology. The cell line included overexpresses Bcl2 target in an untagged form and Bax binding partner fused to PL. When a compound engages the Bcl2 target protein, partner binding is disrupted and the destabilized Bax is degraded, leading to a loss of EFC signal upon addition of EA containing detection reagent. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Target Engagement
Cell Line U2OS
For Use With (Application) Cell Lines
Primary Agonist ABT-737
Quantity 2 Vials
Target Entry Bcl2-Bax
Accession Number NM_000633
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