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DiscoverX InCELL Hunter™ Jurkat RIPK3 Kinase Binding Cell Line

Product Code. 17334829
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Quantity:
2 Vials
Unit Size:
2 ampoules
This item is not returnable. View return policy

Product Code. 17334829

Brand: DiscoverX 960077C19

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This item is not returnable. View return policy

Description

The InCELL Hunter™ Jurkat RIPK3 Kinase Binding Cell Line measures target engagement via compound-induced stabilization of RIPK3 target protein. This cell line ships as two vials of cryopreserved cells.

The InCELL Hunter™ Jurkat RIPK3 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of RIPK3 via detection of RIPK3 levels. This product uses EFC technology. The cell line included overexpresses RIPK3 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.

Specifications

Assay Entry Intracellular Binding
Cell Line Jurkat
For Use With (Application) Cell Lines
Quantity 2 Vials
Target Entry RIPK3
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