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Inavolisib, MedChemExpress

Product Code. 16404646
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Product Code. 16404646

Brand: Medchem Express HY101562

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Description

MedChemExpress GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα.

GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα.

Specifications

Chemical Name or Material Inavolisib
CAS 2060571-02-8
Color Tan
Purity Grade Notes Research
Molecular Formula C18H19F2N5O4
Quantity 100 mg
Synonym GDC-0077 RG6114
Solubility Information DMSO : 110 mg/mL (270.02 mM; Need ultrasonic)
SMILES C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1
Molecular Weight (g/mol) 407.37
Formula Weight 407.37
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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