Invitrogen™ Importin 9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5102881

Product Code. 16659334

Description

Antibody detects endogenous levels of total IPO9.

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6.

Specifications

• Antigen: Importin 9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IPO9
• Gene Alias: 0710008K06Rik; AI845704; C78347; DKFZp761M1547; FLJ10402; HSPC273; Imp9; imp9a; imp9b; importin 9; importin-9; importin-9a; importin-9b; Ipo9; KIAA1192; mKIAA1192; Ran binding protein 9; ran-binding protein 9; RANBP9; RP11-90L20.4
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55705
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q96P70
• Gene Symbols: IPO9
• Immunogen: A synthesized peptide derived from human IPO9(Accession Q96P70), corresponding to amino acid residues G967-Q1017.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG