Invitrogen™ Importin 4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA558634

Product Code. 15746511

Description

Immunogen sequence: AFLPYMESVF EEVFKLLECP HLNVRKAAHE ALGQFCCALH KACQSCPSEP NTAALQAALA RVVPSYMQAV NRERERQVVM AVLE Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 77%.

Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Specifications

• Antigen: Importin 4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ipo4
• Gene Alias: 8430408O15Rik; AA409693; Imp4; Imp4a; IMP4B; importin 4; importin 4a; importin-4; Importin-4a; importin-4b; IPO4; Ran-binding protein 4; ranBP4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79711
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8TEX9
• Gene Symbols: Ipo4
• Immunogen: Recombinant protein corresponding to Human Importin 4. Recombinant protein control fragment (Product #RP-97613).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG