Invitrogen™ IMPDH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA527519

Product Code. 13441627

Description

Recommended positive controls: HepG2, NIH-3T3, JC, BCL-1. Predicted reactivity: Mouse (100%), Rat (99%), Zebrafish (94%), Xenopus laevis (96%), Chicken (96%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

Specifications

• Antigen: IMPDH2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IMPDH2
• Gene Alias: HAMAP-Rule:MF_03156}; IMP (inosine 5'-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP dehydrogenase 2 {ECO:0000255; IMP dehydrogenase type II; IMP oxireductase 2; IMPD; IMPD 2; IMPD 2 {ECO:0000255; IMPD2; IMPDH 2; IMPDH 2 {ECO:0000255; IMPDH II; Impdh2; IMPDH-II; inosine 5' phosphate dehydrogenase 2; inosine 5-monophosphate dehydrogenase 2; inosine 5'-phosphate dehydrogenase 2; inosine monophosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; inosine-5'-monophosphate dehydrogenase 2; inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 23918, 3615
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 2 mg/mL
• Formulation: PBS with 40% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P12268, P24547
• Gene Symbols: IMPDH2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human IMPDH2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG