Invitrogen™ ILP-2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA14276

Product Code. 11538810

Description

PA1-4276 detects the ILP-2 protein in human samples. PA1-4276 has been successfully used in Western blot procedures. PA1-4276 immunogen corresponds to amino acid residues 71-84 of the human ILP-2 protein.

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Specifications

• Antigen: ILP-2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BIRC8
• Gene Alias: baculoviral IAP repeat containing 8; baculoviral IAP repeat-containing 8; baculoviral IAP repeat-containing protein 8; BIRC8; hILP2; IAP-like protein 2; ILP2; ILP-2; inhibitor of apoptosis-like protein 2; testis-specific inhibitor of apoptosis
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 112401
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q96P09
• Gene Symbols: BIRC8
• Immunogen: Synthetic peptide: E(71) E K G H E Y I N N I H L T(84).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG