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Invitrogen™ IL31RA Polyclonal Antibody

Product Code. 15993365
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Quantity:
100 μL
Unit Size:
100µL
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15993365 100 μL 100µL
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Product Code. 15993365 Supplier Invitrogen™ Supplier No. PA576851

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Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL31RA
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene IL31RA
Gene Accession No. Q8K5B1, Q8NI17
Gene Alias class I cytokine receptor; CRL; CRL 3; CRL3; CRL3Glmr; cytokine receptor NR10; cytokine receptor-like 3; GLM R; Glmr; GLM-R; GLM-RMGC125346; GP130 like receptor; gp130-like monocyte receptor; Gp130-like receptor; GPL; HGLM R; HGLMR; hGLM-R; IL 31RA; IL-31 receptor subunit alpha; IL31R subunit alpha; IL-31R subunit alpha; Il31ra; IL-31RA; IL-31RAGPLCRL; IL-31R-alpha; interleukin 31 receptor A; interleukin 31RA; interleukin-31 receptor subunit alpha; MGC125346; mGLM-R; novel cytokine receptor 10; NR10; PLCA 2; PLCA2; PRO21384; soluble type I cytokine receptor CRL3; UNQ6368/PRO21073/PRO21384; ZcytoR17
Gene Symbols IL31RA
Host Species Rabbit
Immunogen Recombinant full length Human IL31RA.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 133396, 218624
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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