Invitrogen™ IL2RG Recombinant Rat Monoclonal Antibody (3E12)

Rat Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA551816

Product Code. 30088744

Description

This conformation-dependent antibody binds to the murine common gamma-chain, shared by the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptor complexes. It recognises an epitope located in a membrane-proximal portion of the common gamma-chain, near Arg-197 of domain 2. This antibody does not cross-react with COS7 cells transfected with rat common gamma-chain cDNA.

IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.

Specifications

• Antigen: IL2RG
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: P34902
• Gene Symbols: IL2RG
• Immunogen: This antibody was raised by immunising Lewis rats with transfected rat myeloma cell line YB2/0, expressing murine cytoplasmic-tailless IL-2R common gamma-chain (YB2/0-myt).
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Flow Cytometry, Inhibition Assays, Immunoprecipitation
• Clone: 3E12
• Conjugate: Unconjugated
• Gene: IL2RG
• Gene Alias: [g]c; Ab2-183; CD132; CD132 antigen; CIDX; common cytokine receptor gamma chain; cytokine receptor common subunit gamma; gamma(c); gammaC; gc; IL-2 receptor subunit gamma; IL2R gamma; IL-2R subunit gamma; IL2RG; IL-2RG; IMD4; interleukin 2 receptor subunit gamma; interleukin 2 receptor, gamma; interleukin 2 receptor, gamma (severe combined immunodeficiency); interleukin 2 receptor, gamma chain; Interleukin-2 receptor subunit gamma; p64; SCIDX; SCIDX1
• Host Species: Rat
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 16186
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid