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Invitrogen™ IL21R Polyclonal Antibody

Product Code. 12868192
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12868192 100 μg 100µg
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Product Code. 12868192 Supplier Invitrogen™ Supplier No. PA519982

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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~60kDa. A suggested positive control is Raji cell lysate. PA5-19982 can be used with blocking peptide PEP-0106.

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL21R
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Il21r
Gene Accession No. Q9HBE5, Q9JHX3
Gene Alias CD360; IL-21 receptor; Il21r; IL-21R; interleukin 21 receptor; interleukin-21 receptor; LR-beta; lymphocyte receptor beta; MGC10967; NILR; novel cytokine receptor 8; Novel interleukin receptor; NR8; UNQ3121/PRO10273
Gene Symbols Il21r
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids 97 to 111 of human IL-21 receptor precursor.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 308977, 50615, 60504
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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