Invitrogen™ IL1RAPL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA596244

Product Code. 16579081

Description

Immunogen sequence: SISLTVGEND TGLCYNSKMK YFEKAELSKS KEISCRDIED FLLPTREPEI LWYKECRTKT WRPSIVFKRD TLLIREVRED D; Positive Samples: A-431, Mouse brain, Mouse heart, Rat brain, Rat heart; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Single-pass type I membrane protein, axon, dendrite.

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signaling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization.

Specifications

• Antigen: IL1RAPL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Il1rapl1
• Gene Alias: 6330532G10Rik; C030039N24; IL1R8; Il1rapl; Il1rapl1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; interleukin 1 receptor accessory protein like 1; interleukin 1 receptor accessory protein-like 1; interleukin 1 receptor-8; interleukin-1 receptor accessory protein-like 1; mental retardation, X-linked 10; MRX10; MRX21; MRX34; Oligophrenin-4; OPHN4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11141, 317553, 331461
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3.07 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P59823, P59824, Q9NZN1
• Gene Symbols: Il1rapl1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human IL1RAPL1 (NP_0550861).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG