Invitrogen™ IL17C Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5103436

Product Code. 16679884

Description

Antibody detects endogenous levels of total IL17C.

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Specifications

• Antigen: IL17C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IL17C
• Gene Alias: CX2; cytokine CX2; Il17c; IL-17C; IL-21; Interleukin; interleukin 17C; interleukin-17C; UNQ561/PRO1122
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 234836, 27189
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8K4C5, Q9P0M4
• Gene Symbols: IL17C
• Immunogen: A synthesized peptide derived from human IL17C(Accession Q9P0M4), corresponding to amino acid residues R141-C191.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG