IL-9 Monoclonal Antibody (D9302C12), Functional Grade, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-7093-025

Product Code. 17141472

Description

This monoclonal D9302C12 antibody reacts with and inhibits the bioactivity of mouse IL-9. IL-9 is a 14 kDa cytokine originally named P40 and identified by its proliferative effects on T cell populations. The receptor, which is a heterodimer of the gamma chain portion of the IL-2 receptor and the IL-9R chain, activates Jak/STAT signaling pathways upon binding its ligand. Since the discovery of IL-9, numerous other functions have been observed. It induces Th17 and Treg differentiation in CD4+ T cells, IgE production in B cells, and the differentiation and proliferation of mast cells. IL-9 expression was initially observed in Th2 cells, but has since been found in Th17, eosinophil, and mast cells. Th9 cells, a newly discovered subset of CD4+ T cells, are characterized by the secretion of large amounts of IL-9 and IL-10. Th9 development is induced by stimulation of undifferentiated CD4+ with IL-4 and TGF beta. Th2 cells can also be driven towards a Th9 phenotype in the presence of TGF beta.

IL-9 Monoclonal antibody specifically detects IL-9 in Mouse samples. It is validated for Functional Assay, Neutralization

Specifications

• Antigen: IL-9
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.2
• Gene Accession No.: P15247
• Host Species: Armenian Hamster
• Quantity: 25 mg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Functional Assay, Neutralization
• Clone: D9302C12
• Conjugate: Functional Grade
• Gene: Il9
• Gene Alias: cytokine P40; homolog of mouse T cell and mast cell growth factor 40; HP40; Il9; IL-9; ILN; Interleukin; interleukin 9; Interleukin9; interleukin-9; P40; p40 cytokine; p40 T-cell and mast cell growth factor; T-cell growth factor p40
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16198
• Content And Storage: 4° C
• Form: Liquid