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IL-6 Polyclonal Antibody, Invitrogen™

Product Code. 10170273
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500 μg
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Each
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10170273 500 μg Each
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Product Code. 10170273 Supplier Invitrogen Supplier No. ARC0062

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Description

Rabbit Polyclonal Antibody

Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells, T cells, B cells, and hepatocytes. In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation, IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.
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Tekniske data

Antigen IL-6
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Gene Il6
Gene Accession No. P20607
Gene Alias B-cell hybridoma growth factor, interleukin HP-1, interleukin-6, BSF2, HGF, HSF, IFNB2
Gene Symbols Il6
Host Species Rabbit
Immunogen Recombit rat IL-6.
Purification Method Purified
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24498
Target Species Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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