Invitrogen™ IL-34 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA520594

Product Code. 12808772

Description

Despite its predicted molecular weight, IL-34 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is human brain tissue lysate. PA5-20594 can be used with blocking peptide PEP-0714.

IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.

Specifications

• Antigen: IL-34
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Il34
• Gene Alias: 2010004A03Rik; AI593503; C16orf77; IL34; IL-34; ILN; Interleukin; interleukin 34; Interleukin34; interleukin-34
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 146433, 498951, 76527
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q4KM46, Q6ZMJ4, Q8R1R4
• Gene Symbols: Il34
• Immunogen: A 13 amino acid peptide from near the center of human IL-34.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG