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Invitrogen™ IL-29 Recombinant Rabbit Monoclonal Antibody (3H21L13)

Product Code. 30828503
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100 μL
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30828503 100 μL
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Product Code. 30828503 Supplier Invitrogen™ Supplier No. 704932

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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

IFN-lambdas constitute a novel family of interferons that mediate the induction of anti-viral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively. Similar to type I IFNs, IFN-lambdas activate an intracellular signaling to promote gene expression. IFN-lambdas mediate their anti-viral protection through a class II cytokine receptor complex composed of two essential receptor proteins, CRF2-12/IFN-lambdaR1, which is unique to IFN-lambdas, and CFR2-4/IL-10R2, which is shared with IL-10, IL-22, and IL-26 receptors. The IFN-lambdas, IL-28 and IL-29, have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. DCs that differentiate in response to IFN-lambdas express high levels of class I and II MHC gene products, but low levels of costimulatory molecules. Moreover, these cells can specifically induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-29
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 3H21L13
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene IFNL1
Gene Accession No. Q8IU54
Gene Alias cytokine Zcyto21; Cytokine Zcyto22; FNL1; IFN lambda1; IFNL1; IFNL3; IFN-lambda-1; IFN-lambda-3; IFN-lambda-4; IL28B; IL-28B; IL28C; IL-28C; IL29; IL-29; ILN; interferon lambda 1; interferon lambda 3; Interferon lambda1; interferon lambda-1; Interferon lambda-3; interferon, lambda 1; interferon, lambda 3; interferon, lambda 4; interferon-lambda-1; Interleukin; interleukin 29 (interferon, lambda 1); interleukin-28B; Interleukin-28C; interleukin-29; ZCYTO21; ZCYTO22
Gene Symbols IFNL1
Host Species Rabbit
Immunogen Peptides corresponding to human IL-29 [aa21-aa34] and [aa182-aa200].
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 282618
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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