IL-25R (IL-17RB) Rat anti-Mouse, eFluor 660, Clone: MUNC33, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-7361-80

25UG Anti-Mouse IL-25R (IL-17RB) eFluor 660

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15580037

Quantity Price
1 £ 138.8 / 25µg
Estimated Shipment date
from Supplier 13-12-2016
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Description and Specification

Specification

Antigen IL-25R (IL-17RB)
Applications Flow Cytometry
Clone MUNC33
Concentration 0.2mg/mL
Conjugate eFluor 660
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Interleukin-25 receptor
Host Species Rat
Isotype IgG2a
Quantity 25μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

This MUNC33 monoclonal antibody reacts with mouse interleukin-25 receptor (IL-25R), also known as IL-17RB. IL-25R is a 55kDa transmembrane protein that dimerizes with IL-17RA to form the functional receptor for IL-25 (IL-17E). IL-25R is detectable in various tissues, including the lung and gastrointestinal tract and exists as both membrane bound and soluble form. IL-25/IL-25R interaction has been shown to activate the NF-kB, MAPK, and JNK pathways as well as gene transcription by STAT6, GATA-3, and NFATc1. IL-25R signals in T helper 2 (Th2) cells, type 2 innate lymphoid (ILC2) cells and some iNKT cells to promote differentiation and effector function. Whereas IL-25-deficient mice have an impaired Th2 response to parasitic helminth infection, elevated expression of IL-25 and IL-25R is observed in patients with chronic asthma and atopic dermatitis.