Invitrogen™ IL-23 p19 Monoclonal Antibody (G23-8), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Product Code	Brand	Quantity
15537816	Invitrogen™ 16-7232-38	5 mg
17141512	Invitrogen™ 16-7232-025	25 mg
17151512	Affymetrix eBioscience 16-7232-050	50 mg

Description

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.

Specifications

• Antigen: IL-23 p19
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with no preservative; pH 7.2
• Gene ID (Entrez): 83430
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Gene: IL23A

• Clone: G23-8
• Applications: ELISA, Functional Assay, Neutralization, Western Blot
• Conjugate: Functional Grade
• Host Species: Rat
• Target Species: Mouse
• Gene Accession No.: Q9EQ14
• Isotype: IgG1 κ
• Purification Method: Affinity chromatography
• Product Type: Antibody