Invitrogen™ IL-22 Receptor alpha Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5144626

Product Code. 17920773

Description

Positive control: 293T cell lysate, HepG2 cell lysate, K562 cell lysate, Hela, SiHa, mouse kidney tissue, rat pancreas tissue. Predicted band size: 63 kDa Subcellular Location: Membrane.

A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

Specifications

• Antigen: IL-22 Receptor alpha
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Il22ra1
• Gene Alias: 9130219A07Rik; CRF2-9; Cytokine receptor class-II member 9; cytokine receptor family 2 member 9; ENSMUSG00000073746; il-22 receptor; IL-22 receptor subunit alpha-1; IL22R; IL-22R; IL22R1; IL22RA1; IL-22RA1; IL-22R-alpha-1; ILN; Interleukin; interleukin 22 receptor subunit alpha 1; interleukin 22 receptor, alpha 1; interleukin-22 receptor alpha chain; interleukin-22 receptor subunit alpha-1; RGD1559655; zcytoR11
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 230828, 362629, 58985
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q80XZ4, Q8N6P7
• Gene Symbols: Il22ra1
• Immunogen: Synthetic peptide within human IL-22RA1 aa 1-50/574.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG