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Invitrogen™ IL-21 Polyclonal Antibody

Product Code. 12858192
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12858192 100 μg 100µg
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Product Code. 12858192 Supplier Invitrogen™ Supplier No. PA519981

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Description

Rabbit Polyclonal Antibody

Suggested positive controls are Human Tonsil, Mouse Spleen, or Rat Spleen Lysate. PA5-19981 can be used with blocking peptide PEP-0105. Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (87%). At least two isoforms of IL-21 are known to exist; this antibody will detect both isoforms. IL-21 antibody is predicted to not cross-react with other members of the interleukin protein family.

IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells. In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6. As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function. IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells. In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23. While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3. IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules. In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IL-21
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene IL21
Gene Accession No. A3QPB9, Q9ES17, Q9HBE4
Gene Alias CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
Gene Symbols IL21
Host Species Rabbit
Immunogen A peptide corresponding to 15 amino acids near the center of human IL-21 precursor. The immunogen is located within the last 50 amino acids of IL-21.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 365769, 59067, 60505
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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