Invitrogen™ IL-20RB Monoclonal Antibody (20RNTC), eBioscience™

Rat Monoclonal Antibody

Product Code	Brand	Quantity
17120562	Invitrogen™ 14-1206-37	2 mg
15287187	Invitrogen™ 14-1206-82	100 μg

Description

Description: This 20RNTC monoclonal antibody recognizes mouse and human IL-20R2 (interleukin-20 receptor 2, IL-20Rb) in either of its two heterodimeric complexes formed by pairing with IL-20R1 or IL-22R1. IL-20R2 belongs to the class II cytokine receptor family that shares a characteristic pattern of cysteine, proline and tryptophan residues in the extracellular domain. IL-20R2 paired with IL-20R1 forms a receptor that binds IL-20, IL-19, or IL-24. IL-20R2 paired with IL22R1 forms a receptor that binds IL-20 or IL-24. The IL-20R complex signals primarily via the JAK-STAT pathway. IL-20R2 is found predominantly on cells of epithelial origin such as gut and skin and can be upregulated during inflammation. Immunofluorescent staining of A375 cells reveals a punctate staining pattern at the cell membrane, as well as diffuse, cytoplasmic staining that is likely associated with protein synthesis and transport in the endoplasmic reticulum and golgi. Applications Reported: This 20RNTC antibody has been reported for use in immunocytochemistry, immunoblotting (WB) and flow cytometric analysis. Applications Tested: This 20RNTC antibody has been tested by immunofluorescent staining and flow cytometric analysis of fixed and permeabilized A375 cells. This can be used between 1-10 μg/mL. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009].

Specifications

• Antigen: IL-20RB
• Concentration: 0.5 mg/mL
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rat
• Regulatory Status: RUO
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q6UXL0
• Gene ID (Entrez): 213208, 53833
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Clone: 20RNTC
• Content And Storage: 4°C
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG2a κ
• Target Species: Human, Mouse
• Gene: Il20rb
• Gene Alias: AV228068; DIRS1; Fibronectin type III domain containing 6; FNDC6; Gm186; IL-20 receptor subunit beta; IL20R2; IL-20R2; IL20RB; IL-20RB; IL-20R-beta; interleukin 20 receptor beta; interleukin 20 receptor beta subunit; interleukin 20 receptor subunit beta; interleukin-20 receptor II; interleukin-20 receptor subunit beta; RGD1566151; UNQ557/PRO1114
• Gene Symbols: Il20rb
• Product Type: Antibody