Invitrogen™ IL-17F Recombinant Rabbit Monoclonal Antibody (K03_1K04)

Rabbit Recombinant Monoclonal Antibody

Product Code	Brand	Quantity
30824666	Invitrogen™ MA563114	100 μL
30827825	Invitrogen™ MA564573	50 μL

Description

IL-17F Recombinant Monoclonal Antibody for IHC (P)

IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.

Specifications

• Antigen: IL-17F
• Concentration: 1 mg/mL
• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
• Gene Accession No.: Q96PD4
• Gene ID (Entrez): 112744
• Immunogen: Recombinant human IL17-F protein.
• Product Type: Antibody

• Clone: K03_1K04
• Content And Storage: Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: IL17F
• Gene Alias: C87042; CANDF6; cytokine ML-1; IL17F; IL-17F; IL-24; ILN; Interleukin; interleukin 17F; Interleukin17F; interleukin-17F; interleukin-24; ML1; ML-1; mutant IL-17F
• Gene Symbols: IL17F
• Primary or Secondary: Primary
• Purification Method: Protein A/G