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IL-17F Monoclonal Antibody (eBio18F10), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£85.25 - £262.00
Specifications
Antigen | IL-17F |
---|---|
Clone | eBio18F10 |
Concentration | 0.2mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15549366
|
Affymetrix eBioscience
46-7471-82 |
100 μg |
£262.00
100µg |
Estimated Shipment: 10-05-2024 Log in to see stock. |
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15539366
|
Affymetrix eBioscience
46-7471-80 |
25 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Interleukin 17F is a cytokine belonging to the IL-17 family,that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflamation by increasing chemokine production.
IL-17F (Interleukin 17F, CTLA-8)) is a cytokine belonging to the IL-17 family that is produced by inflammatory cells such as activated T cells, mast cells, and basophils. IL-17F is involved in allergic airway inflammation, and can induce several cytokines, chemokines, and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. IL-17F may be secreted as a homodimer, or a heterodimer with IL17A. It acts by binding to the type I receptor, IL-17R, aiding recruitment of monocytes and neutrophils at the site of inflammation by increasing chemokine production. IL-17F also stimulates induction of other pro-inflammatory cytokines TNF alpha, IL-1 beta, IL-6, and IL-8, and reports strongly suggest the involvement of IL-17 in several chronic inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis. TGF-beta (differentiation) and IL-23 (expansion) are required for induction and maintenance of Th17 (IL-17 producing) cells, which in turn induce the other pro-inflammatory cytokines. IL-17F is produced, and exists, as a homo-dimer, with homology to a herpes virus early protein, is one of the six members (IL-17A-F) of this cytokine family, and is well characterized and highly expressed by activated effector memory T cells. IL-17F has been found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.Specifications
IL-17F | |
0.2mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2 | |
IL-17F, ML-1, ML1 | |
Il17f | |
Primary | |
Store at 2-8°C. Do not freeze. Light-sensitive material. | |
Il17f |
eBio18F10 | |
Flow Cytometry | |
PerCP-eFluor 710 | |
Rat | |
Mouse | |
Q7TNI7 | |
257630 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.