IL-12 Rat anti-Mouse, Clone: C18.2, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-7122-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278017

Quantity Price
1 £ 146.13 / 500µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Applications Cytokine Neutralization
Applications ELISA Capture
Gene Alias Interleukin-12
Host Species Rat
Species Reactivity Mouse
Concentration 0.5mg/mL
Format Purified
Conjugate Unlabeled
Primary or Secondary Primary
Isotype IgG2a
Clone C18.2
Antigen IL-12
Quantity 500μg
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C.

The C18.2 antibody reacts with the p35 subunit of mouse interleukin-12 (IL-12). Interleukin-12 (IL-12) is a heterodimeric 70 kD (p70) cytokine composed of two covalently linked, glycosylated chains, 40kD (p40) and 35-kD (p35). IL-12 is mainly produced by monocytes, macrophages, and dendritic cells in response to bacterial products such as lipopolysaccharides (LPS), to intracellular pathogens or upon interaction with activated T cells. IL-12 was originally discovered because of its ability to induce interferon-gamma (IFN-g) production, cell proliferation, and cytotoxicity mediated by natural killer cells and T cells. It is now established that IL-12 also plays a key role in the development of Th1 responses, leading to IFN-g and IL-2 production. These cytokines can in turn promote T-cell responses and macrophage activation.