Invitrogen™ IKK epsilon Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA587387

Product Code. 16595881

Description

Positive Samples: SW480, DU145, MCF7, Mouse liver; Cellular Location: Cytoplasm, Nucleus, PML body Immunogen sequence: SRLRTLAEVL SRCSQNITET QESLSSLNRE LVKSRDQVHE DRSIQQIQCC LDKMNFIYKQ FKKSRMRPGL GYNEEQIHKL DKVNFSHLAK RLLQVFQEEC VQKYQASLVT HGKRMRVVHE TRNHLRLVGC SVAACNTEAQ GVQESLSKLL EELSHQLLQD RAKGAQASPP PIAPYPSPTR KDLLLHMQEL CEGMKLLASD LLDNNRIIER LNRVPAPPDV.

IKBKE is an activator of nuclear factor-kappa-B. Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i. IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1. IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.

Specifications

• Antigen: IKK epsilon
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IKBKE
• Gene Alias: AW558201; I-kappa-B kinase epsilon; Ikbke; IKKE; IKK-E; IKKepsilon; IKK-epsilon; IKKI; IKK-i; IKK-related kinase epsilon; inducible I kappa-B kinase; inducible IkappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; RP11-534L20.1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 363984, 56489, 9641
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.58 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q14164, Q9R0T8
• Gene Symbols: IKBKE
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 497-716 of human IKK? (NP_0547211).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG