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Invitrogen™ IgM Mouse Uncoated ELISA Kit

Uncoated ELISA Kit

£301.00 - £499.00


Products 2
Product Code Brand Description Price Quantity & Availability  
Product Code Brand Description Price Quantity & Availability  
15580907
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Invitrogen™
88-50470-77
20 x 96 Tests £499.00
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15500917
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Invitrogen™
88-50470-88
10 x 96 Tests £301.00
Pack of 10 View alternative products
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»
In stock, ready to ship: 4
Add to basket
 
Description

Description

Immunoglobulin M is the third most common serum Ig and can exist as both a pentamer and as a monomer (e.g. found on B lymphocytes as B - cell receptors). The large pentameric structure allows for building of bridges between encountered epitopes on molecules that are too distant as to be connected by smaller IgG antibodies. IgM is built as the first antibody during an immune response and is responsible for agglutination and cytolytic reactions since ist pentameric structure gives it 10 free antigen binding sites in theory and it posseses a high avidity. Due to conformational constraints among the 10 Fab portions, IgM only has a valence of 5. Additionally, IgM is not as versatile as IgG, but it is of vital importance in complement activation and agglutination. IgM is predominantly found in the lymph fluid and the blood and is a very effective neutralizing agent in the early stages of disease. Elevated levels can be a sign of recent infection or exposure to antigen.