missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. 11894211

Invitrogen™ IFNAR2 Monoclonal Antibody (MMHAR-2)
GREENER_CHOICE

Product Code. 11894211
Change view
Click to view available options
Quantity:
50 μg
Unit Size:
50µg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity unitSize
11894211 50 μg 50µg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 11894211 Supplier Invitrogen™ Supplier No. 213851

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Mouse Monoclonal Antibody

This antibody neutralizes human IFN-alpha receptor, interacting with the extracellular domain. It binds to human IFN-alpha receptor with high affinity and blocks biological action of Type I IFNs. To measure bioactivity, interferon was titrated with the use of a cytopathic effect inhibition assay, where one neutralization unit is the amount of antiserum required to neutralize one unit of human interferon alpha to a 50% endpoint. In this antiviral assay, approximately one unit/mL of interferon was necessary to produce a cytopathic effect of 50%. Purity is >95% by SDS-PAGE and endotoxin level <1 EU/ug. Store at -20°C for up to 6 months. For long-term storage, store at -70°C for retention of full activity. Thaw product by incubation in cold water and aliquot into separate vials, adding 0.1% BSA for additional stability. Refreeze product using a dry ice or a dry ice/alcohol bath. Packaged by and distributed for PBL Assay Science.

The type I interferons, IFN-alpha and IFN-beta, are a group of structurally and functionally related proteins that are induced by either viruses or double-stranded RNA and are defined by their ability to confer an antiviral state in cells. IFN-alpha and IFN-beta appear to compete with one another for binding to a common cell surface receptor, while immune IFN (IFN-gamma) binds to a distinct receptor. This distinct receptor, IFN-alphaR, is only weakly responsive to type I interferons, in contrast to IFN-alpha/betaR, which binds to and responds effectively to IFN-beta and to several of the IFN-alpha subtypes. IFN-alpha/betaR is expressed as two alternatively spliced transcripts, designated IFN-alpha/betaRalpha (IFN-alpha/betaR1) and IFN-alpha/betaRbeta (IFN-alpha/betaR2), both of which are involved in signal transduction and ligand binding.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IFNAR2
Applications Functional Assay, Neutralization
Classification Monoclonal
Clone MMHAR-2
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene IFNAR2
Gene Accession No. P48551
Gene Alias AI747302; human interferon alpha/beta receptor; IFN alpha/betaRbeta; IFN R2; IFNABR; IFNalpha/beta R2; IFN-alpha/beta receptor 2; IFNalpha/betaR2; IFN-alpha/betaR2; IFN-alpha/betaRbeta; IFNalpha/beta-Rbeta; IFN-alpha-REC; IFNAR2; Ifnar-2; IFNARB; IFN-R; IFNR2; IFN-R-2; IMD45; interferon (alpha and beta) receptor 2; interferon (alpha, beta and omega) receptor 2; interferon alpha and beta receptor subunit 2; interferon alpha binding protein; Interferon alpha/beta receptor 2; interferon receptor 2c; interferon-alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; type I interferon alpha/beta receptor 2a; type I interferon receptor 2
Gene Symbols IFNAR2
Host Species Mouse
Immunogen Human interferon alpha/beta receptor chain 2.
Purification Method Ion-exchange chromatography, Size-exclusion chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3455
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.