Invitrogen™ Rat IFN-beta Recombinant Protein

Product Code.	Quantity	unitSize
10280384	1 x 10^5 units	Each

Product Code. 10280384 Supplier Invitrogen™ Supplier No. 134001

Description

Recombinant Protein

After receipt, this product should be kept at -20°C while lyophilized and at -70°C after reconstitution in sterile distilled water for retention of full activity. After reconstitution, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. After thawing, this product is stable for at least four weeks at 4°C. Further dilute only in buffers containing protein such as 0.1% bovine serum albumin (BSA).

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

Specifications

• Accession Number: P01575, P70499
• For Use With (Application): ELISA, Immunoprecipitation, Western Blot
• Formulation: PBS with 0.125 M trehalose and no preservative
• Gene ID (Entrez): 15977, 24481
• Molecular Weight (g/mol): 19.68 kDa
• Name: Rat IFN-beta
• Quantity: 1 x 10^5 units
• Source: Hamster
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: Fibroblast interferon; Ifb; IFF; IFN b; IFN β; IFNB; Ifnb1; IFNbeta; IFN-beta; IFNβ; Interferon; Interferon b; Interferon beta; interferon beta 1; interferon beta 1, fibroblast; interferon beta protein; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
• Common Name: IFN beta
• Gene Symbol: Ifnb1
• Biological Activity: EC50 ̃ 1 U/mL; determined by use of the cytopathic effect inhibition assay described in [Rubinstein, S. et al. (1981). J. Virol. 37, 755-758 ]; [Familletti, P.C. et al. (1981). Methods in Enzymology, Vol. 78, 387-394 ]As there is no international Rat IFN-alpha standard, units are determined with respect to the international reference standard for mouse interferon alpha/beta (mouse IFN-alpha/beta) provided by the National Institutes of Health.
• Conjugate: Unconjugated
• Species: Rat
• Recombinant: Recombinant
• Content And Storage: 4°C
• Expression System: CHO cells
• Form: Lyophilized
• Protein Subtype: Recombinant
• Purity or Quality Grade: >95%